Altered pressure-natriuresis relationship in young spontaneously hypertensive rats.
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منابع مشابه
Altered pressure-natriuresis relationship in young spontaneously hypertensive rats.
In the present study, the pressure-natriuretic responses of 3- to 5- and 6- to 9-week-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) were characterized to determine whether the relationship between sodium excretion and renal perfusion pressure is altered during the development of hypertension. Differences in the neural tone and renal hormone levels in SHR and WKY were min...
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This study examined whether the calcium antagonist nisoidipine can shift the relations between sodium excretion, papillary blood flow, renal interstitial pressure, and renal perfusion pressure toward lower pressures in spontaneously hypertensive rats. Mean arterial pressure decreased similarly by 9% and 12% in Wistar-Kyoto and spontaneously hypertensive rats after nisoidipine (0.5 /xg/kg bolus+...
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We tested the hypothesis that the exaggerated natriuretJc response of spontaneously hypertensive rats (SHR) to intragastric volume expansion may be independent of the sustained level of arterial pressure. The SHRs were treated for 10 days with guanethldine S04, 25 mg/llter, and hydralazine HO, 80 mg/liter, in drinking water. Mean arterial pressure (MAP) in conscious treated SHRs (T-SHR) was 130...
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Although it has been extensively scrutinized, the factor(s) involved in the initiation and development of hypertension in spontaneously hypertensive rats (SHRs) remains unresolved. The objective of the present study was to determine whether, early in development, the causal mechanism(s) for the development of hypertension in young SHRs involves an integration of 2 processes, specifically an upr...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1987
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.9.6_pt_2.iii130